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Testosterone Cypionate Properties

Testosterone Cypionate is one of the many esterified variants of Testosterone available, and is most likely the second most popular esterified variant (the first being Testosterone Enanthate). It is an injectable form of Testosterone with a slow rate of release and a longer half-life. However, the release rates and half-life of both Testosterone Cypionate and Testosterone Enanthate are very much identical and the two compounds are easily interchangeable (for example, an individual can easily run a 10 week cycle of Testosterone and switch between Testosterone Enanthate and Testosterone Cypionate seamlessly). Testosterone Cypionate possesses a half-life of approximately 12 days while Testosterone Enanthate possesses a half-life of approximately 10 days – hardly much difference. The interesting fact about Testosterone Cypionate, however, is that it seems to have a distinct favor of popularity among American bodybuilders and athletes over the Enanthate variant. These distinctions are not extreme, however, and the commonality of use and availability of both variants is almost equal with Testosterone Enanthate ever so slightly more popular. Neither variant possesses any advantages over the other.

 Testosterone Cypionate is simply Testosterone with the Cypionate ester bound to the Testosterone chemical structure. Specifically ‘Cypionate’ is Cypionic acid, but once bound to Testosterone it is properly referred to in chemistry as an ester bond (or ester linkage). Cypionic acid is chemically bound to the 17-beta hydroxyl group on the Testosterone structure. Esterified anabolic hold a greater degree of solubility in fats, and therefore release slower from the injection site in comparison to un-esterified Testosterone – however, this is not the main reason as to why esters extend the release rate and half-life of the given anabolic steroid it is attached to. The primary reason for the augmentation of its half-life and release rate is due to the fact that when Testosterone Cypionate enters the bloodstream, enzymes will bind to the Testosterone Cypionate molecule and break the bond between the ester and the hormone, which takes a varying amount of time depending on the size of the ester in question. This is why larger esters such as Cypionate, Enanthate, Decanoate, and so forth all possess longer half-lives than the smaller shorter esters such as Propionate, Phenylpropionate, Acetate, etc. Therefore, the end result is that the ester is removed from the hormone via enzymes, and what is left over following this chemical interaction is pure Testosterone that is free to do its work in the body. This process of enzymes cleaving off the ester from the Testosterone molecule is what is ultimately responsible for the slower release rates. Pure Testosterone alone with no ester bonded to it possesses a half-life of approximately 2 – 4 hours. When the Cypionate ester is attached to it, creating Testosterone Cypionate, the half-life of Testosterone is now extended to 12 days, which results in a slower release and activity of the hormone.

Properties of Testosterone Cypionate

Testosterone Cypionate’s attributes and expressive properties follows what any individual would expect from Testosterone preparation, with the exception of the differing release rates and half-lives. It must be made clear right now to the reader that Testosterone is very much literally the original anabolic steroid, which is manufactured endogenously naturally in all humans and in the vast majority of animal species. Two important facts result from this: 1. Testosterone is utilized as the base measurement by which all other anabolic steroids are measured against, and, 2. Because Testosterone is the most natural anabolic steroid already manufactured by the human body, Testosterone is considered the safest anabolic steroid for use, as every individual’s body is already accustomed to the effects of Testosterone only to a lesser degree. Essentially, the use of Testosterone for the purpose of physique and performance enhancement is simply the supplementation of additional Testosterone – this could easily be defined as the practice of administering (either through injection or ingestion) more of a hormone into the body that it already manufactures and utilizes.

Daily and Weekly Timing of Oral Anabolic Steroids

For anabolic effect, it’s most efficient for levels to be as sustained as possible across the day, within reason. We could compare, for example, taking Dianabol as 50 mg once per day or as 10 mg five times per day.

On the once-daily dosing, you’d have about a 5 or 6 hour period with blood levels as high or higher than in the multiple-dosing case. But for the rest of the day, levels would be lower, usually far lower. For the last 10 hours or more, they’d be uselessly low.

Now that might work fine if the very high levels of the first few hours multiplied the effect during that period, but that’s not the case. Ongoing 10 mg dosing already about maximizes the effect of Dianabol.
During the earlier part of the day the two dosing plans give about the same activity as with the frequent lower dosing, but for most of the day the once-daily plan gives less activity.

It doesn’t take a full 5 times per day to give a good result. For Dianabol, I think 3x/day is reasonable as a minimum, though personally I prefer 4x or 5x/day.

Oxandrolone (Anavar), oxymetholone (Anadrol), and stanozolol (Winstrol) all have longer half-lives than Dianabol does. As a result, they may be dosed less frequently. For these, 2x/day is a reasonable minimum, though I prefer 3x or 4x/day.

As for which days of the week should receive orals, again sustained levels are the most efficient, where the only purpose is anabolism. Using orals every day is best. However, some like taking orals pre-workout and relying only on injected steroids for the rest of the week. Where the choice of injected anabolic steroids is sufficient and suitable by itself, then this is fine.

But if the steroid stack depends on the orals, then use the orals every day. It’s entirely acceptable though to shift timing of orals to pre-workout and/or post-workout if you wish, or to add orals at those times. When adding orals at these times, total daily dosage should still be kept within typical amounts.

In some cases the purpose of orals is increased training aggression. When used for this, make sure the rest of the steroid stack will work by itself as intended, and then use orals for best effect pre-workout.

Jul 9

Steroid Cycle Bridging and Cruising

Steroid Cycle Bridging is a process to bridge two steroid cycles together with a compound what wont restrict recovery of your endogenous hormone production and hopefully still be able to possibly carry on gaining or at least hold onto all the new tissue gained within the completed steroid cycle. The ideal bridging hormones would be Hgh, Igf and slin these would allow full recovery of your HPTA and if your diet and training are in order you should maintain the new tissue what you have gain from the finished cycle and in some cases produce further gains.

Ive seen good results and excellent blood work to support the dbol bridge protocol where only around 10mgs of dbol is used in the morning and still be able to recover your HPTA or at least recover nearly all function, yet again i feel this is an individual thing and some still find it hard to recover but ive had amazing results using this method. Ive heard some use low suppression compounds during this phase and they can recover their HPTA, i feel that coming from a cycle what as had your shut down for a few wks to swap to low suppression compounds to recover your HPTA wont have much effect and will still hinder recover greatly or at least ive experienced this, again depends on what compounds your coming off, but seems pointless trying to recover when your still taking hormones what will stop or hinder full recovery IMHO..

Bodybuilders who bridge with other steroids are only asking for trouble in the long run, infact its not bridging if your not allowing your HPTA to recover its cruising. With ever successive cycle after a cruise you will be building up tolerance within the body and greater amounts of gear will be needed to try and get new growth from the future cycles, your slowly destroying your own hormonal system by saturating it with anabolic steroids and Hormone Replacement Therapy will be the only answer and do you want to pin yourself for the rest of your life sooner than you should be doing. Ive cruised and bridge many times and without doubt you hold and produce some amazing gains the benefits are outstanding but at what cost! aging BB’s seem to have no choice because of their natural test wont support muscle tissue and so Hormone Replacement Therapy comes into play. Considering cruising between cycles needs proper research and knowing exactly what your getting yourself into, I wouldn’t recommend it unless your competing to be at a high level, pro status or your willing to take the risk of permanent damage.

Recovery of your HPTA is vital to maintaining your gains, some bodybuilders run longer cycles protocol’s and shutdown their own hormone production for a very long time, the longer your shutdown the harder it is to recovery or at least the majority it is, shorter cycles are better for you HPTA and recovery. Would you rather shutdown your own system for 20 weeks or 6weeks? the shorter the better for recovery but also the compounds used within these cycles will make a big difference to how quick you recover, some weak low suppression compounds will be far easier to regain function but then again will you gain any kind of muscle from these products

The harder the recovery the more chance of losing the vital muscle tissue gained within the cycle because of the natural Test not supporting any of the new found gains. Many bodybuilders go back on to soon and run cycles to close together because of this reason and problems can occur in the long run. Proper time off is needed to re-fresh your system and produce greater gains in your future cycles, a good solid PCT protocol will help with recovering full function of your HPTA which in turn will support and maintain the gains from the cycle, bridging with compounds what wont suppress or shut you down would be a good option which i describe in at the start of this thread. For me cruising and running cycles to close together will produce some serious sides what will effort you for the rest of your life but the decision is yours just remember the risk’s.

Jul 1

Trenbolone Side Effects: Night Sweats and Reduced Cardio Capacity

Both reduced cardio and night sweats are somewhat common complaints with trenbolone users, though in the majority of cases neither occurs.

The cardiovascular capacity problem is in at least some cases related to elevated hematocrit. It’s worth checking.

At the highest level of competitive cycling, it’s well known that athletes have sought high hematocrit levels. With high hematocrit, they’ve been able to sustain increased power output. Or in other words, their cardio performance was better.

However, this isn’t a general rule. Along with higher oxygen carrying capacity, along with higher hematocrit comes higher blood viscosity, or greater blood thickness. Even where hematocrit is remaining within the normal range, one study found that aerobic capacity of other athletes may be superior with midrange or even low-midrange hematocrit than with high-normal values.

It’s possible for hematocrit to go substantially above normal during an anabolic steroid cycle. Since you are seeing an adverse side effect, I’d check hematocrit level. If it is at about 53 or higher, I’d discontinue anabolic steroid use for now.

If hematocrit is in the normal range, then there’s no known answer for the reduced cardio ability. Some have speculated that lung irritation might be the cause. I don’t know of medical evidence, but don’t rule out that there could be truth to it.

To deal with the cardio issue, some trenbolone users limit their dose to for example 50 mg/day rather than 75 or 100 mg/day. Trenbolone is so effective per milligram that even 50 mg/day provides an excellent effect as part of a steroid stack.

As for night sweats, I know of no convincing explanation for this problem. It seems to strike randomly. Commonly, for the same individual it will occur in some cycles but not others. There seems no solution but getting the bedroom as cool as possible and using beach towels to absorb the sweat. At least the night sweats may be helping to burn off fat.

Oral Turinabol Chlordehydromethyltestosterone

Oral Turinabol is one of those substances that has gained what I would call a “quiet cult status” amongst bodybuilders. It was first developed by scientists in East Germany for use by their Olympic athletes. The success achieved by those athletes is testament to its effectiveness. The fact that it was used extensively for enhancing sports performance also meant that it was subject to many trials with documented results proving very impressive.

So what does Oral Turinabol have to offer that is so special?

Well it does provide good lean muscle gains and, although strength and muscle increases will not be as dramatic as with some other compounds, they will be less likely to be accompanied by water retention. This means that you are more likely to keep any gains made when coming off a cycle. In addition to this, Oral Turinabol does not create estrogen related side effects (e.g. gynecomastia) although it is 17-alpha alkylated which means it can be toxic to the liver so it is wise to use some form of liver support when on a cycle (e.g. Silymarin, Dandelion, NAC).

Oral Turinabol has been described as a derivative of Dianabol although it does have a much lower level of androgenic activity. Studies have revealed it to have anywhere from 0 � 6 in terms of androgenic effects and 53 for anabolic effects (based on a score of 100 each for testosterone). This means that it will not give you the bloated, puffy look often observed by those who use Dianabol. In fact, many users have compared it to Anavar in terms of results.

SIDE EFFECTS

Negative side effects are rare with this substance and are usually the result of using cycles that are either too long or too high in dosage. The aforementioned risk of liver toxicity and a lowering of the clotting ability of the blood are the only things to really look out for. It has also been implicated as regards the lowering of natural testosterone levels, but once again this is generally dose related. There have been reports of women suffering more adverse side effects than men when using this substance, however these reactions occurred in women who were taking almost double the amount taken by their male counterparts, of course they would get more side effects!

DOSAGE

It has been recommended that men should take between 20-40mg every day and women 5-10mg/day. However, in real life terms male bodybuilders usually prefer an amount of 0.4mg per pound of bodyweight.
One of the many interesting things about Oral Turinabol is its ability to reduce SHBG’s binding to other steroids, which leads to the freeing up of more testosterone in the body. For this reason many athletes find it a valuable accompaniment to any cycle, particularly those involving the use of testosterone. The fact that Oral Turinabol is not associated with aromatization (i.e. conversion to estrogen) also adds to its attractiveness.

All in all, when you consider the fact that it produces little in the way of troublesome side effects (when used in reasonable dosages) and produces a high quality gain in muscle mass over time, Oral Turinabol is definitely worth considering as part of an effective cycle. Even used on its own it will definitely produce a noticeable improvement in mass and strength. The gains will not be astounding but they will be more easily maintained since the improvements made on Oral Turinabol are not an illusion created by water weight

CJC-1295 Dosage

The information below relates to using GHRH Peptides (CJC-1295 DAC and Modified GRF 1-29) as standalone products.

Growth Hormone Releasing Hormones (GHRH): include Modified GRF 1-29(Cjc1295) and CJC-1295 DAC, are peptides which stimulate the pituitary gland to release stores of the body’s natural Growth Hormone (GH).

Recommended Dosages
Modified GRF 1-29 Dose per injection: 100mcg Injections per vial: 20 x 100mcg dosages Amount to Inject: If you have used 1ml of water for mixing then a 100mcg dosage = 0.05ml (or 5 units on Insulin Syringe). If you have used 2ml of water for mixing then 100mcg = 0.10ml (or 10 units) and if you have used 3ml of water for mixing, then 100mcg = 0.15ml (or 15 units).

CJC-1295 DAC Dose per injection: 2mg Injections per vial: 1 x 2mg dosages Amount to Inject: If you have used 0.5ml of water for mixing then a 2mg dosage = 0.50ml (or 50 units on Insulin Syringe). If you have used 1ml of water then a 2mg dosage = 1ml (or 100 units).

Injection Frequency

Modified GRF 1-29 100mcg injected 1-3 times per day, preferably together with a GHRP Peptide at 100-200mcg.

CJC-1295 DAC 2mg injected once per week (due to its long half-life)

Diet Restrictions

Modified GRF 1-29 Pre-injection: The purpose of injection Modified GRF 1-29 is to have it trigger a release of GH in the body. Since fat and insulin (released after eating carbohydrates) both diminish the release of GH you should refrain from consuming any high fat or high carbohydrate meals or beverages for at least 2 hours before your injection (assuming you are injecting Modified GRF 1-29 on its own). An example of this would be eating dinner at 8pm then waiting until at least 10pm to do your injection. If you are however combining it with a GHRP peptide, studies in animals have indicated that when these peptides were taken together just 1 hour after eating their ability to release GH wasn’t diminished. Therefore if your schedule is not so flexible in regard to meal timings, you may wish to combine Modified GRF 1-29 with a GHRP peptide.

Post-injection: 30 minutes post-injection is usually when GHRH stimulation of GH release is complete, meaning it’s safe to consume food/beverages after this time without worrying that they will cause your injection to be less effective. Consuming a high protein/carbohydrate meal at this time will create an insulin spike and therefore assist with the anabolic (muscle building) effects of GH. Those looking to burn fat should wait as long as possible before eating and when you do, only eat high protein, low fat and low carbohydrate meals to allow GH’s fat burning effects to last as long as possible.

CJC-1295 DAC

Due to its long half-life no dietary restrictions are required for CJC-1295 DAC to exhibit its long-term benefits on your body’s basal GH level, however, observing the same instructions as above for Modified GRF 1-29 will ensure you also take advantage of the short-term GH pulse created after a CJC-1295 DAC injection.

Recommended Diet Cutting: High Protein with moderate fat and low carbohydrates since insulin (primarily realized in response to carbohydrates being consumed) will stop GH’s fat burning effects while it’s present.

Bulking: High Protein, high carbohydrates, and low fat. While insulin stops GH’s fat loss properties, it is required for GH to be anabolic (muscle building), so you should always aim to spike your insulin 30 minutes post injection.

Jun 4

CHEST NASSER EL SONBATY WORKOUT

ONE OF THE MOST POPULAR competitors in the IFBB, Nasser El Sonbaty has heaved plenty of weight in his 15 years as a pro. Like most of his peers, he changes his workouts often, but this particular routine is a great example of how he combines presses and flyes for a more intense, and thus more productive, session.
» “A technique that works well for me is rest/pause,” Nasser explains. “I may do a set of 6–10 reps on an incline dumbbell press, pause for 10 seconds, do another 4–5 reps, rest again and finish with 1–3 reps.”
» Nasser recommends choosing a heavy weight, but not so heavy that you can’t get at least 6 reps in the set.

FLAT-BENCH DUMBBELL FLYE
START: With a dumbbell in each hand and a slight but unchanging bend in your elbows, lie on a flat bench and allow the weights to travel out and away from your body in a wide arc.
MOVE: Feel the stretch, then contract your pecs to forcefully raise the weights overhead while keeping the angle in your elbows nearly constant.



DECLINE DUMBBELL FLYE
START: When he does the decline press with dumbbells, Nasser will go right into the decline flye as the second half of a compound set. With a weight heavy enough for presses, he doesn’t get a really deep stretch at the bottom but still strives for a decent range of motion. Lie back on a decline bench and hold a pair of dumbbells overhead, keeping your hands in a neutral (palms-facing) position.
MOVE: Maintaining a slight bend in your elbows throughout, power the weights up in a wide arc, keeping constant tension on your chest by not locking out at the top nor allowing the weights to rest against each other. When lowering the weights, fight gravity to gain the benefit of the negative.

DECLINE DUMBBELL PRESS
START: Lie back on a decline bench and hold the weights directly over your pecs.
MOVE: Resist the negative as you lower the dumbbells until they just touch your lower-chest region. In a forceful movement, power the weights up but don’t lock out. “I think ‘squeeze the pecs’ at the top,” Nasser adds.

Sustanon 250 Testosterone Blend

Sustanon 250 is the trade name for a mixture (or ‘blend’) of 4 different variations of esterified Testosterone in a particular ratio. It typically contains: 30mg of Testosterone Propionate, 60mg of Testosterone Phenylpropionate, 60mg of Testosterone Isocaproate, and 100mg of Testosterone Decanoate for a total of 250mg worth of combined Testosterone esters (hence the number 250 in the name Sustanon 250). The idea in combining all of these different Testosterone esters is to provide a Testosterone drug that will provide the user with both a fast immediate release of Testosterone followed by a slower more extended release. The opposite of such a drug would be single forms of esterified Testosterone, such as a Testosterone Propionate product, which, of course, contains nothing but Testosterone Propionate in the vial.

Sustanon was developed and manufactured by Organon and it was in the early 1970s that it entered the market. The idea behind it was to provide a preparation of Testosterone that would have an advantage over single esterified Testosterone products in a medical and clinical setting. The idea here was also that of convenience, as Sustanon 250 requires more infrequent injections than does Testosterone Propionate or Testosterone Suspension, for example. What is interesting to note is that Sustanon 250 was never approved for use or sale in the United States, but Sustanon 250 remains a very popular drug on the international market. Sustanon 250 is most likely one of the most popular Testosterone preparations in use by bodybuilders and athletes. It was commonly thought that this was the case due to misconception that its more potent than single esterified forms of Testosterone, but this is not true. Esters attached to different anabolic steroids only affect the half-life and release time of whatever anabolic steroid they are bound to. In the case of Sustanon 250, there are four different esterified types of Testosterone to be considered – but Sustanon 250 is no more ‘potent’ of a Testosterone product than a straight Testosterone Enanthate preparation, for example.

The real true and primary reason for its popularity among athletes and bodybuilders is instead the amount of steroid one is getting for the money spent. A blend of four different esterified Testosterone variants is considered a great value for the money spent in comparison to the purchase of a single esterified Testosterone variant. However, over the years this price difference has not proven to be extremely advantageous over other forms of Testosterone. The sheer truth of the matter is that Sust 250 was not developed for athletes and bodybuilders, but instead with medical application in mind, and it is therefore an optimized product for those requiring medical treatment from it. The idea with this product was to provide patients with a far more convenient and comfortable dosing schedule where administration of the drug is concerned. Many patients prescribed it need only to worry about an injection every 3 – 4 weeks. As a bodybuilder or athlete, this is very unrealistic seeing as though athletes and bodybuilders would require injections of this product weekly, and blood plasma levels of Testosterone as a result would end up peaking to the same levels in the same amount of time that any other type of Testosterone product would end up doing. Therefore, the perceived benefits of Sustanon really do not apply to bodybuilders or athletes, or to individuals looking to use it for the purpose of performance/physique enhancement.

Chemical Characteristics of Sustanon 250

Sustanon 250, as previously mentioned is a precise blend of four different types of esterified Testosterone variants. Each of these Testosterone variants are molecules of Testosterone with esters chemically bonded to them at the 17th carbon position of the Testosterone structure (these esters are Propionate, Phenylpropionate, Isocaproate, and Decanoate). The addition of these esters slows down the rate of release of Testosterone into the bloodstream, which results in augmented half-lives of the different esterified forms of Testosterone. For example, Testosterone itself with no ester attached to it possesses a half-life of approximately 2 – 4 hours. When the Propionate ester is attached to it, for example, creating Testosterone Propionate, the half-life of Testosterone is now extended to 4.5 days, providing a slower release and activity of the hormone. Once in the body, enzymes work to cleave off and remove the attached ester from the Testosterone molecule, of which the end result is pure Testosterone free to do its job in the body. The process of enzymes removing the ester is what is responsible for the varying half-lives and release times of the different esterified variants.

Sustanon 250 itself with all of its Testosterone variants as a whole is designed to provide an initial fast peak of blood plasma Testosterone levels in approximately 24 – 48 hours following administration. After this, blood plasma levels of Testosterone are to remain elevated for a 21 day period due to the longer esterified Testosterone variants in the mix. The goal and the idea behind the development and marketing of this injectable was to primarily treat Testosterone deficient men and with the unique release rates of Sustanon 250, this is almost exclusively what the product was designed, intended, and used for.

Properties of Sustanon 250

The properties of Sust 250 is what one would expect from any Testosterone preparation. It is important to remember that Sustanon 250 is simply only Testosterone with a mixture of different release times. Therefore, the typical properties and effects are exactly what any expectations would be from Testosterone.

Testosterone is literally the original anabolic steroid, produced naturally within all humans and most animal species. It is considered the safest anabolic steroid one could use, due to the fact that it is the hormone that each individual’s body already produces, already uses, and is already accustomed to. Therefore, the use of Testosterone for the purpose of performance and physique enhancement is simply the equivalent of introducing more of a hormone into the human body that it already manufactures and uses.

Coming off Anabolic Steroids

Anabolic steroids come in many forms including injections and pills Many people are hesitant to consult a physician when dealing with anabolic steroids abuse.  Although anabolic steroids are illegal, and speaking to a doctor can be daunting, it is the first hurdle on the road to recovery.  The biggest mistake one can make when deciding to come off of an anabolic steroids cycle is to simply stop taking the drugs altogether.  Steroids are powerful hormones, and sometimes simply discontinuing usage can cause as many problems as using them.

The “bridge” is a term used to describe the gap in time from when anabolic steroids are eliminated from your system, to when the body again starts the production of natural testosterone.

During this time there is a shift in the hormonal balance between estrogen and testosterone, in which the former is elevated and the latter is very low or nonexistent.  Medical assistance and the use of prescribed medications can make this transition more manageable by eliminating or significantly reducing this timeframe, as well as minimizing the number and severity of potential side effects.  Frequently, a doctor will requisition blood tests to properly dose medicine and further assess internal damage.  After thoroughly evaluating your condition, an effective course of action can be recommended.  Such action may involve immediate discontinuation, or a gradual tapering of drugs to permit the body to more slowly normalize.

Seek medical professionals for help with steroid abuseThe first step in speaking to a doctor about coming off steroids is to gather the necessary information regarding your steroid use.  It is therefore important to be open and honest regarding every aspect of your steroid history including:  all of the drugs taken (steroids & ancillaries); the length of usage; your dosages & scheduling habits; and any experienced physical & mental side effects.  Since anabolic steroids are sold under many names, in several countries, and on the black market, it is recommended that the patient bring a list of all of the products taken, and if possible the actual purchased containers.

The cessation of physical activity when coming off steroids is a very common mistake.  Physical training helps to keep endorphins high, staves off depression, helps to maintain a healthy cardiovascular system, and plays an important role in maintaining general health.  Be sure to consume an adequate and balanced diet including lots of water.  Be certain to follow your physician’s instructions regarding dietary supplements such as vitamins, minerals and anti-oxidants.
                               
Similar to mind altering drugs, the potential for addiction to anabolic steroids is very real.  Such mental and emotional complications should not be confronted alone.  Your doctor may be able to recommend a counselor who is qualified to assist in this final and necessary step to ending anabolic steroids abuse.

May 7

Using Tamoxifen In Anabolic Steroid Cycle

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Tamoxifen is an oral anti-estrogen/estrogen antagonist prescription drug. Tamoxifen is commonly referred to as an anti-estrogen, but technically it is more of an estrogen antagonist. An estrogen antagonist has a unique way of preventing estrogen activity. What it does is to compete with estrogen at the receptor sites, occupying it so that estrogen cannot bind with it.

Tamoxifen is an anticancer drug which is reportedly effective in treating breast cancer, particularly the kind that is induced by estrogen. Its other therapeutic uses include reduction of the risk of invasive breast cancer following surgery and radiation therapy for ductal carcinoma in situ. Tamoxifen is also used as preventive drug. It is prescribed in women who are at high risk of developing breast cancer (genetic disposition).

Why is there a need for Tamoxifen

During a steroid cycle, Tamoxifen is used by bodybuilders who are sensitive to estrogen buildup. Estrogen buildup can lead to many concerns, foremost of these is the occurrence of gynecomastia (growth of breast tissues in men) and subcutaneous fat and water retention.

During PCT, Tamoxifen is effective in averting the dreaded effect when coming off a steroid cycle – the post-cycle crash. This is basically losing what you have gained when you’re on a cycle. Bodybuilders, in general, use Tamoxifen to block this from taking place.

Here’s the scenario. When a bodybuilder is taking anabolic steroids, the body ceases its production of androgens. When he stops taking them, the body does not immediately resume its normal production of these hormones, resulting to depressed androgen level. When this happens the body compensates by overproducing estrogen. The excess estrogen, in turn, results to can increase the production of SHBG and blocks testosterone-receptor sites. SHBG or sex hormone-binding globulin is a glycoprotein that binds to sex hormones, including testosterone. And so, if there’s an increase in the amount of SHBG in the system it translates to lesser amount of free or unbound testosterone. This means there are two mechanisms by which excess estrogen interferes with the normalization of androgen level in the body.

Furthermore, a depressed androgen level can lead to catabolism. There are many signals that induce catabolism and this includes cortisol, which is considered to be one of the ‘classic’ catabolic hormones. Cortisol plays a great role in protein catabolism, which is the breakdown of macromolecules. Macromolecules include proteins and lipids (fat). When protein catabolism takes place, there is a subsequent loss in muscle gains and strength. Your muscles get leaner because fat, water, and protein substrates break down. However, this is not to say that this is a completely negative effect as some bodybuilders prefer leaner muscles. But for those who are after bulk or mass this poses a problem. This is why Tamoxifen is not advised for those whose aim is to gain mass.

Tamoxifen vs aromatase inhibitors

Tamoxifen is usually compared to aromatase inhibitors like Arimidex; however, there is a distinct difference between these two classes of drugs. Estrogen agonists or anti-estrogens (also classified as triphenylethylenes) do not halt the production of estrogens whereas aromatase inhibitors do quite effectively.

Aromatase blockers or inhibitors halt the natural production of estrogen and therefore tend to completely suppress estrogenic activity, including its beneficial roles in body (metabolism, lipid profile, protein synthesis). This is why many still opt for Tamoxifen as an ancillary and recovery drug.

Further, Tamoxifen exerts its effects faster vis-à-vis an aromatase inhibitor. Thus, when bodybuilders experience the symptoms of gynecomastia while they are on steroid cycle, they rely on Tamoxifen to immediately counter the problem. However, a drawback of this drug is that it exhibits only short-term effects, which means that once Tamoxifen intake is discontinued, the same problems can possibly rebound sooner than later. To prevent this rebound, Tamoxifen is generally use in conjunction with aromatase inhibitor. Tamoxifen can deal with the problem right away while an aromatase inhibitor like Arimidex can work for the long-term results as it reduces the production of estrogen.

Tamoxifen Dosage

Dosage ranges from 10mg – 60mg daily.

Tamoxifen is recommended to be stacked with highly aromatizable steroids like Dianabol and testosterone.

It is important to start a PCT once you finished a steroid cycle to avoid a dramatic loss of the mass gained. The question on how soon to initiate a PCT depends on the kind of steroids you used. If your cycle is comprised of orals, which have relatively the shortest effect on the body, it is advised to start immediately. Some say PCT can begin as early as the last day of the steroid cycle. If short-acting esters or water-based injectables, PCT is recommended 4-7 days after the last injection. In the case of long-acting esters, it should be around 10-14 days after the last injection.

Side effects are reportedly few and mild with this drug. Nausea, vomiting and hot flashes can be experienced by users of Tamoxifen.

High dosage can prevent natural testosterone production by the testes. Further, high dosage can be counter-productive; that instead of lowering estrogenic levels, it increases the levels. This is a consequence when the adrenal glands are overly stimulated to produce the prohormone dehydroepiandrosterone or DHEA. DHEA converts to estrogen.